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KMID : 0370219840280040237
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Yakhak Hoeji
1984 Volume.28 No. 4 p.237 ~ p.241
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Effects of alpha-Adrenergic Drugs on Castor Oil Induced Diarrhea in Rats
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허인회/Huh IH
이도익/이종훈/김동휘/Lee DI/Lee JH/Kim DW
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Abstract
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The effect of lofexidine, clonidine, and other drugs on castor oil induced diarrhea in rats was investigated. Castor oil was administered orally and drugs were administered intraperitoneally. The results were as follows. 1. Lofexidine(0.1-3mcmol/kg) blocked dose dependently castor oil-induced diarrhea like clonidine, but its potency was weaker than that of clonidine. 2. Yohimbine (1-10mcmol/kg) antagonized the antidiarrheal action of lofexidine and clonidine. 3. Prazosin (3-30mcmol/kg) did not antagonize the antidiarrheal action of lofexidine and clonidine. 4. Metoclopramide, bromocriptine mesylate, and nadolol did not affect antidiarrheal action of lofexidine significantly. 5. Loperamid prolonged the antidiarrheal action of lofexidine.
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